Role of ratios of neutrophil and monocyte to lymphocyte and red cell distribution width to platelet in the detection of early onset neonatal sepsis in comparison with serum C-reactive protein

Introduction and Aim: Early onset neonatal sepsis (EONS) is a preventable cause of mortality morbidity. Blood culture, the current gold standard has turn-around time 48 to 72 hours high false negatives. Thus, there need for reliable biomarkers its early detection. The present study aims find utility ratios derived from components complete blood count in detecting EONS. Materials Methods: laboratory investigations neonates with without clinical were recorded using purposive convenience sampling technique. total leucocyte count, absolute neutrophil C-reactive protein (CRP) counts compared by Mann Whitney test. Their performance was then analysed receiver operating characteristic analysis. Results: A 196 aged 0 3 days considered study, out which 98 cases group. Serum CRP red cell distribution width platelet (RPR) found have statistical significance, albeit low sensitivity specificity detection Positive correlation RPR (p value=0.001). area under curve 0.661 0.628 respectively. However, no significant difference monocyte lymphocyte between comparative groups. Conclusion: In background yield culture positivity longer turnaround time, can be used as biomarker diagnosis EONS conjunction CRP.